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Contrast Media Manufacturing Company

For the purpose of medical imaging, a certain substance is introduced into the human body to change the image contrast of local tissues of the body. This introduced substance is Contrast Media, also known as Contrast Agents. As the first Contrast Media manufacturer in China, Beilu Pharma, as one of the most professional contrast media companies, launched the domestic MRI Contrast Media Gadopentetate Dimeglumine Injection in 1992, which broke the foreign products monopoly and filled the domestic gap. As a well-known contrast media company, we could provide various types of MRI contrast and a broad portfolio stems Contrast Media across CT/X-ray and MRI modalities, and own the EU standard manufacturing facilities.

Types of Contrast Media in Beilu Pharma

Magnetic Resonance Imaging (MRI)Contrast Media is Gadolinium based contrast agent(GBCA). It is an intravenous injection, mainly used to enhance the image quality of internal organs, blood vessels and tissues during MRI examinations. GBCA contains gadolinium, which is connected to each other through carrier molecules to form a chelating agent. According to the different chemical structures, this contrast medium can be divided into two categories: linear and macrocyclic. The linear structure of the imaging agents is easier to release gadolinium ions, and the macrocyclic structure of the contrast material is more stable and less likely to release gadolinium ions.
Gadopentetate Dimeglumine Injection/API Gadopentetate Dimeglumine Injection/API
Gadobutrol Injection/API Gadobutrol Injection/API
Gadobenate Dimeglumine Injection Gadobenate Dimeglumine Injection
Ferric Ammonium Citrate Effervescent Granules Ferric Ammonium Citrate Effervescent Granules
Iodine-containing Contrast Media is one of the common imaging contrast agents used in radiology diagnosis and interventional therapy. It is also a basic diagnosis drug for cardiovascular imaging under X-ray. Currently, the iodinated Contrast Media used for cardiovascular system CT and digital subtraction angiography are all water-soluble organic iodinated contrast materials.
Iohexol Injection Iohexol Injection
Iopamidol Injection Iopamidol Injection
Iodixanol Injection Iodixanol Injection

Our dedication to your requirements, providing a full range of Contrast Media products

Finished Types of Contrast Media

S. No

Product name




Gadopentetate Dimeglumine Injection

Injectable solution

469mg/ml:  10ml, 12ml, 15ml, 20ml


Gadobutrol Injection

Injectable solution

604.72mg/ml:  7.5ml


Ammonium iron citrate

Oral granules

3g:0.6g(Fe 129mg)

6g:1.2g(Fe 258mg)


Iopamidol Injection

Injectable solution

300mgI/ml:  50ml, 100ml

370mgI/ml:  50ml, 100ml


Iodixanol Injection

Injectable solution

270mgI/ml:  100ml

320mgI/ml:  50ml, 100ml


Iohexol Injection

Injectable solution

300mgI/ml:  20ml,50ml,75ml, 100ml

350mgI/ml:  20ml, 50ml, 100ml

API & Intermediates Types of Contrast Media

S. NoProductsCAS NO.PackingsClassification
1Iohexol66108-95-025kgContrast agent
2Iodixanol92339-11-225kgContrast agent
73334-07-325kgContrast agent
4Iopamidol60166-93-025kgContrast agent
87771-40-225kgContrast agent
6Gadopentetate Monomeglumine92923-57-425kgContrast agent
7Gadopentetate Dimeglumine86050-77-325kgContrast agent
8Gadobutrol138071-82-625kgContrast agent
11Diethylenetriaminepentaacetic acid ( Pentaacetic Acid)(DTPA)67-43-62.5kgIntermediates
12Iopamidol Intermediate (order based) 5-Amino-2,4,6-triiodoisophthalic acid


Comparison of physicochemical characteristics of commonly used Contrast Media

Contrast media


Osmotic pressure

(mOsm/kg water)



Iopamidol 300



Ioverol 300



Iohexol 300



Iobitridol 300



Iodixanol 320



The osmotic pressure of normal people is about 290-300mOsm/kg.

Taking the viscosity of water as 1, when the temperature is 37℃, the relative viscosity of whole blood is 4-5, and the relative viscosity of plasma is 1.6-2.4.

Three factors of renal injury induced by Contrast Media: Osmotic pressure, Viscosity and the total iodine. Reduced iodine intake is a feasible strategy to avoid kidney damage.

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